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- Title
Kallikrein-Related Peptidase 7 in Salivary Gland Tumours: Immunohistochemical Expression Profile.
- Authors
Hashem, Nelly N.; Mohamed, Mohamed; Irene Zhang; Fung, Kevin; Kwan, Keith; Mara, Thomas W.; Daley, Thomas D.; Diamandis, Eleftherios P.; Darling, Mark R.
- Abstract
Purpose: To determine the expression of kallikrein-related peptidase (KLK) 7 in three types of salivary gland tumour. Methods: A standard immunoperoxidase staining technique was used to assess the immunohistochemical expression profile of KLK7 in normal salivary glands and three types of salivary gland tumour: pleomorphic adenoma (PA; n = 22), adenoid cystic carcinoma (ACC; n = 14), and mucoepidermoid carcinoma (MEC; n = 10). Tumour grade, tumour stage, patient age at diagnosis, gender, and site of tumour occurrence were individually correlated with KLK7 levels in MEC and ACC. Results: Normal salivary glands, PA, ACC, and MEC show strong expression of KLK7 in the ductal and nonductal cells. Both PA and ACC showed substantially higher KLK7 levels than do normal glands and MEC tissue. There were no statistically significant associations between levels of KLK7 and tumour stage, tumour grade, patient age, gender, or site of tumour. Conclusions: The elevated KLK7 expression in PA and ACC compared with MEC suggests a role for KLK7 in tumours of myoepithelial differentiation. Moreover, the co-expression of KLK7 with other kallikreins and their lack of specificity to a single type of salivary gland tumour may suggest the possible involvement of KLK7 in an enzymatic pathway activated in the tumorigenesis of myoepithelial cells. Further studies are needed to quantitatively measure KLK7 messenger ribonucleic acid (mRNA) expression levels in salivary gland tumours and to correlate them with prospective clinical data
- Subjects
SALIVARY gland tumors; KALLIKREIN; PEPTIDASE; IMMUNOHISTOCHEMISTRY; ADENOID cystic carcinoma
- Publication
Canadian Journal of Pathology, 2011, Vol 3, Issue 3, p12
- ISSN
1918-915X
- Publication type
Article