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- Title
Vitamin D Status and Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study in a Tertiary-Level Hospital in Antananarivo, Madagascar.
- Authors
Raharinavalona, Sitraka Angelo; Raherison, Rija Eric; Miandrisoa, Rija Mikhaël; Andrianasolo, Radonirina Lazasoa; Rakotomalala, Andrianirina Dave Patrick
- Abstract
To determine the vitamin D status of Malagasy with T2DM seen at the Soavinandriana Hospital Center, and the association between hypovitaminosis D and CRF. Methods: This was a cross-sectional study, carried out over a period of 2 years. Assayed by the chemiluminescence technique, vitamin D was "normal", "insufficient" and "deficient" if the 25-hydroxyvitamin D plasma was ≥ 30 ng/mL, 20– 29 ng/mL and ≤ 19 ng/mL, respectively. Hypovitaminosis D was the set of vitamin D insufficiency and deficiency. Results: Among the 318 T2DM, the prevalence of hypovitaminosis D was 66.0% (45.2% insufficiency and 20.8% deficiency). Their factors associated were age ≥ 70 years (OR = 2.15 [1.26– 3.66]), glycated haemoglobin ≥ 7% (4.97 [2.97– 8.39]), and retinopathy (OR = 4.15 [1.85– 9.32]). After adjustment for age, Hb A1c ≥ 7% and retinopathy, hypovitaminosis D was associated with hypertension (OR = 8.77 [4.76– 16.2]), dyslipidaemia (OR = 8.05 [3.98– 14.5]), ex-smoking (OR = 6.07 [2.78– 13.3]), microalbuminuria (OR = 2.95 [1.25– 6.97]) and carotid atherosclerosis (OR = 2.96 [1.83– 4.35]). Conclusion: Hypovitaminosis D was common in T2DM. Its treatment is primarily preventive. It is also important to control associated CRF, diabetes and its complications.
- Subjects
ANTANANARIVO (Madagascar); MADAGASCAR; TYPE 2 diabetes; CARDIOVASCULAR diseases risk factors; DISEASE risk factors; VITAMIN D deficiency; CARDIOVASCULAR fitness; VITAMIN D; CROSS-sectional method
- Publication
Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2024, Vol 17, p2191
- ISSN
1178-7007
- Publication type
Article
- DOI
10.2147/DMSO.S467316