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- Title
Image analysis of Stage 1 melanoma (1.00-2.50mm): lymphocytic infiltrates related to metastasis and survival.
- Authors
Pastorfide, G. C.; Kibbi, A.-G.; de Roa, A. L.; Barnhill, R. L.; Sober, A. J.; Mihm Jr., M. C.; Byers, H. R.
- Abstract
Image analysis of histologic sections of 11 patients with clinical Stage melanoma, 1.00 mm-2.50 mm, who developed metastasis, was done to determine the significance of lymphocytic infiltrates relative to metastasis and survival. An age sex, site, and thickness matched control group of non-metastasizing clinical Stage 1 melanoma revealed no significant difference in the lymphocytic' infiltrate parameters from the metastasizing group with the exception of the ratio of lymphocyte infiltrate width to the tumor width (p = 0.003). Increased lymphocytic infitrates within the tumor and subjacent to its bas significantly correlated with delayed time metastasis (p=0.014 and p<0.001, respectively) and longer survival period (p = 0.045 and p <0.001, respectively). Lymphocytic infiltrate area at the tumor base in relation to tumor area was of prognostic value: the larger the ratio, the greater the time interval from metastasis to death (p = 1.008).
- Subjects
MELANOMA; METASTASIS; PATHOLOGY; NEUROENDOCRINE tumors; TUMORS; PATIENTS
- Publication
Journal of Cutaneous Pathology, 1992, Vol 19, Issue 5, p390
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1992.tb00611.x