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- Title
Mutant p53 expression in solar keratosis: an immunohistochemical study.
- Authors
Sim, C. S.; Slater, S.; McKee, P. H.
- Abstract
Thirty-eight solar keratoses from 32 patients were studied for expression of mutant p53 protein by an immunohistochemical technique. Twenty-eight of the 38 solar keratoses (73.7%) showed positive and variable nuclear labelIing, whereas 10 specimens were immunonegative. The nuclear immunopositivity which was seen in all variants was mostly diffuse in distribution. The adjacent "normal" epidermis of 8 keratoses showed positive mutant p53 labelIing. Eight of the keratoses were associated with invasive squamous cell carcinoma of which only two were immunopositive. Cytoplasmic labelling was never a feature. The study demonstrates that mutant p53 protein is commonly expressed in all variants of solar keratosis and that its expression correlates with atypical keratinocyte proliferation. It is proposed that the demonstration of mutant p53 in the adjacent normal epidermis may be a potential marker of early neoplastic transformation.
- Subjects
KERATOSIS; PROTEINS; IMMUNOHISTOCHEMISTRY; EPIDERMIS; SQUAMOUS cell carcinoma; KERATINOCYTES
- Publication
Journal of Cutaneous Pathology, 1992, Vol 19, Issue 4, p302
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1992.tb01366.x