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- Title
Combined measurement of fasting plasma glucose and A1C is effective for the prediction of type 2 diabetes: the Kansai Healthcare Study.
- Authors
Sato KK; Hayashi T; Harita N; Yoneda T; Nakamura Y; Endo G; Kambe H; Sato, Kyoko Kogawa; Hayashi, Tomoshige; Harita, Nobuko; Yoneda, Takeshi; Nakamura, Yoshiko; Endo, Ginji; Kambe, Hiroshi
- Abstract
<bold>Objective: </bold>We prospectively assessed whether the combined measurements of fasting plasma glucose (FPG) and A1C were effective for predicting type 2 diabetes.<bold>Research Design and Methods: </bold>Study participants included 6,736 nondiabetic Japanese men aged 40-55 years. Type 2 diabetes was diagnosed in those who had an FPG >or=126 mg/dl or who were being treated with an oral antidiabetic agent or insulin. The models including FPG, A1C, and both were compared using the area under the receiver operating characteristic (AUROC) curves.<bold>Results: </bold>During the 4-year follow-up period, we confirmed 659 diabetes cases. In multivariate analysis, both FPG and A1C were independently associated with the risk of type 2 diabetes. The model including both FPG and A1C had a greater AUROC curve than that including FPG alone (0.853 vs. 0.818; P < 0.001) or A1C alone (0.853 vs. 0.771; P < 0.001).<bold>Conclusions: </bold>The combined measurement of FPG and A1C was effective for predicting type 2 diabetes.
- Publication
Diabetes Care, 2009, Vol 32, Issue 4, p644
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc08-1631