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- Title
Comparative Approach to the Evaluation of Hemoglobin A<sub>2</sub> by Two Different Methods: High-Performance Liquid Chromatography and DE-52 Microchromatography.
- Authors
Samperi, P.; Testa, R.; Mancuso, M.; Schilirò, G.
- Abstract
Hb A2 was determined in 477 subjects: 77 were affected by iron deficiency anemia, 172 were carriers of β -thalassemia trait and 228 were normal controls. Hb A2 was determined by both DE-52 microchromatography and high-performance liquid chromatography (HPLC). The analysis of the data by linear regression demonstrated that the methods furnish overlapping results. Our findings show that HPLC is a rapid and easily reproduced method which allows a quantitative and qualitative discrimination of the various Hb fractions, making it a valid tool in screening programs for hemoglobinopathies. Copyright © 1990 S. Karger AG, Basel
- Publication
Acta Haematologica, 1990, Vol 83, Issue 4, p179
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000205209