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- Title
Malformaciones congénitas en hijos de madres epilépticas con y sin tratamiento con anticonvulsivantes.
- Authors
Arteaga-Vázquez, Jazmín; Luna-Muñoz, Leonora; Mutchinick, Osvaldo M.
- Abstract
Objective. To determine the prevalence at birth and type of congenital malformations (CM) in newborns of epileptic mothers (NEM) treated and not treated with anticonvulsants, the correlation anticonvulsant/CM and other developmental disorders. Materials and methods. Multicenter case-control study, in 166 live births NEM diagnosed in 21 501 newborns with CM and respective controls from the Registro y Vigilancia Epidemiológica de Malformaciones Congénitas (RYVEMCE). Results. The frequency of CM in NEM treated with anticonvulsants was higher (48.3%) than in NEM of untreated mothers (28.3%), (OR= 2.37 IC95% 1.08-5.40), p=0.03. CMs most frequently found were: spina bifida, limb reduction defects, cleft lip palate, microcephaly, anotia/mi- crotia, hypospadias, polydactyly, cleft palate, anophthalmia/ microphthalmia and omphalocele. No differences among monotherapy and polytherapy were observed. Diphenyl- hydantoin, carbamazepine and valproic acid were the most frequently anticonvulsants used. Conclusions. Our results show the teratogenicity of epilepsy by itself, the synergistic effect of some anticonvulsants, and the need of an appropriate periconceptional control of the disease and treatment.
- Subjects
HUMAN abnormalities; CHILDREN of epileptics; ANTICONVULSANTS; EPILEPSY risk factors; TERATOGENESIS
- Publication
Salud Pública de México, 2012, Vol 54, Issue 6, p579
- ISSN
0036-3634
- Publication type
Article
- DOI
10.1590/S0036-36342012000600006