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- Title
Wide dissemination of Gram-negative bacteria producing the taniborbactam-resistant NDM-9 variant: a One Health concern.
- Authors
Terrier, Christophe Le; Nordmann, Patrice; Buchs, Chloé; Di, Doris Yoong Wen; Rossolini, Gian Maria; Stephan, Roger; Castanheira, Mariana; Poirel, Laurent
- Abstract
However, using a panel of isogenic recombinant I Escherichia coli i strains producing a variety of MBLs, including NDM enzymes, we recently showed that NDM-9, differing from NDM-1 by a single amino acid substitution (E152K), was not inhibited by taniborbactam.[5] Here we report the I in vitro i activity of cefepime/taniborbactam in comparison with other recently developed BL/BLI combinations against a collection of NDM-9 producers. The increasing trend of carbapenem resistance observed in Gram-negative bacteria is mainly related to the dissemination of carbapenemase-encoding genes.[1] A particular threat are those encoding MBLs, since production of MBLs leads to very limited treatment options.[1] MBLs of the NDM group have been largely disseminated in human, animals and in the environment, making them the most frequently identified acquired carbapenemases worldwide.[1],[2] NDM-like -lactamases hydrolyse all -lactams (BLs) except monobactams, and are not inactivated by most of the recently developed -lactamase inhibitors (BLIs) (avibactam, relebactam, vaborbactam, nacubactam or zidebactam).[3] The newly developed cyclic boronate BLI, taniborbactam, alias VNRX-5313, is one of the few BLIs possessing significant inhibitory activity against MBLs, with the exception of IMP-like enzymes, and is currently in clinical development in combination with cefepime (https://clinicaltrials.gov/ct2/show/NCT03840148).[4] Hence, the combination cefepime/taniborbactam displays excellent I in vitro i activity against NDM-producing Gram-negative isolates worldwide.
- Subjects
GRAM-negative bacteria; ENTEROBACTERIACEAE; KLEBSIELLA pneumoniae; LACTAMS; WHOLE genome sequencing
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2023, Vol 78, Issue 9, p2382
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkad210