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- Title
Metabolomic analysis of epigallocatechin-gallate (EGCG)-treated human lymph node prostate carcinoma (LNCaP) cell line.
- Authors
Ibeawuchi-Onuoha, Chinyere; Teichert, Friederike
- Abstract
EGCG (Epigallocatechin-gallate) is frequently studied and the observed effects show potentials in prostate chemoprevention. The mechanism of action EGCG has on prostate cancer cells is still not fully understood. However through metabolic profiling, the effect of EGCG on prostate cancer cells could be elucidated and potential metabolic targets identified. Here, the metabolic profile of EGCG treated LNCaP cells (n = 6) were compared to untreated controls (n = 6). Comparatively, there were significant changes in the metabolic levels of lactate, citrate, aspartate, succinate, asparagine, glycine and adenine nucleotides. The findings suggest that the polyphenol EGCG is effective in deregulating the metabolism of prostate cancer cells by targeting the Krebs cycle.
- Subjects
EPIGALLOCATECHIN gallate; CHEMOPREVENTION; PROSTATE cancer treatment
- Publication
Biokemistri, 2017, p12
- ISSN
0795-8080
- Publication type
Article