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- Title
Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats.
- Authors
Petronilho, Fabricia; Florentino, Drielly; Silvestre, Fernanda; Danielski, Lucineia; Nascimento, Diego; Vieira, Andriele; Kanis, Luiz; Fortunato, Jucelia; Badawy, Marwa; Barichello, Tatiana; Quevedo, Joao
- Abstract
The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 % λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx.
- Subjects
LUNG injuries; ORGANOSELENIUM compounds; CARRAGEENANS; PLEURISY; LACTATE dehydrogenase; LABORATORY rats; OXIDATIVE stress; ANTI-inflammatory agents; THERAPEUTICS
- Publication
Inflammation, 2015, Vol 38, Issue 4, p1394
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-015-0113-5