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- Title
Sec14l3 Is Specifically Expressed in Mouse Airway Ciliated Cells.
- Authors
Shan, Lihua; Noritake, Shinobu; Fujiwara, Masatoshi; Asano, Satoshi; Yoshida-Noro, Chikako; Noro, Nobuhiro; Yamashita, Keizo; Kawakami, Takao
- Abstract
Airway epithelium is a key component for airway integrity. Previously, we found that expression of the Sec14l3 gene that encodes a 45-kDa secretory protein is inversely associated with the progression of experimentally induced airway inflammation and degeneration/necrosis of alveolar epithelium. In this report, using in situ hybridization we demonstrated that the ciliated cells in mouse lung selectively express Sec14l3 mRNA. In a three-dimensional culture of mouse tracheal epithelial cells, levels of the Sec14l3 mRNA correlated with the differentiation of ciliated cells. Intranasal infection of adult mice with influenza virus resulted in a 20-fold, progressive decrease in Sec14l3 mRNA expression over 10 days post infection. These results enhance the potential value of Sec14l3 as a ciliated epithelial cell-specific biomarker for the progression of airway inflammations such as airway viral infection and asthma.
- Subjects
AIRWAY (Anatomy); EPITHELIUM; LABORATORY mice; INFLAMMATION; NECROSIS; MESSENGER RNA; INFLUENZA viruses; ASTHMA
- Publication
Inflammation, 2012, Vol 35, Issue 2, p702
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-011-9363-z