We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action.
- Authors
Chen, Jin-Fang; Wu, Shi-Wei; Shi, Zi-Man; Hu, Bing
- Abstract
Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis, and its development involves abnormalities in multiple signaling pathways. Surgery, chemotherapy, radiotherapy, target therapy, and immunotherapy remain the main treatments for CRC, but improvement in the overall survival rate and quality of life is urgently needed. Traditional Chinese medicine (TCM) has a long history of preventing and treating CRC. It could affect CRC cell proliferation, apoptosis, cell cycle, migration, invasion, autophagy, epithelial–mesenchymal transition, angiogenesis, and chemoresistance by regulating multiple signaling pathways, such as PI3K/Akt, NF-κB, MAPK, Wnt/β-catenin, epidermal growth factor receptors, p53, TGF-β, mTOR, Hedgehog, and immunomodulatory signaling pathways. In this paper, the main signaling pathways and potential targets of TCM and its active ingredients in the treatment of CRC were systematically summarized, providing a theoretical basis for treating CRC with TCM and new ideas for further exploring the pathogenesis of CRC and developing new anti-CRC drugs.
- Subjects
PHYTOTHERAPY; RISK of metastasis; MEDICINAL plants; CELL migration; MICROBIOLOGICAL assay; AUTOPHAGY; EPIDERMAL growth factor receptors; APOPTOSIS; IMMUNOMODULATORS; COLORECTAL cancer; CELLULAR signal transduction; CELL cycle; QUALITY of life; CELL proliferation; CHINESE medicine; OVERALL survival
- Publication
Chinese Medicine, 2023, Vol 18, Issue 1, p1
- ISSN
1749-8546
- Publication type
Article
- DOI
10.1186/s13020-023-00719-7