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- Title
Vitamin A, D and zinc serum levels in children with and without acute respiratory tract infection in two university hospitals.
- Authors
Javadi-Nia, Shima; Noorbakhsh, Samileh; Izadi, Anahita; Shokrollahi, Mohammad Reza; Asgarian, Ramin; Tabatabaei, Azardokht
- Abstract
Background: Severity of respiratory infection in children is depended on various factors such as causative organism and the host immunologic response to the organism. Vitamins and micronutrients play an important role in this response with supporting the immune system and therefore, the response to infections. Nutritional deprivations in children, especially vitamins and micronutrients such as zinc, vitamin A and vitamin D are very common in middle east and other countries in Asia, which is due to inappropriate diet and nutrient loss in recurrent infections. This study aimed to evaluate the serum levels of vitamins A, D and zinc in hospitalized children aged six months to five years. Methods: This analytic cross-sectional study was performed in 65 children aged six months to five years who were hospitalized in pediatric and surgical wards of Rasul Akram Hospital and Bahrami Hospital in Tehran. All of samples were evaluated according to WHO cri-teria for acute respiratory infection, and underwent measurement of serum vitamin A, vitamin D and zinc levels by using Atomic, Elisa and spectrophotometer methods. Results: Serum levels of vitamins A in patients with acute respiratory infection was 0.27±0.16 μg/ml and in children without infection was 0.41±0.2 μg/ml, that different wasn't statistically significant (P=0.4). Serum levels of vitamins D in patients with acute respiratory infection was 35.37±34.68 ng/ml and in children without infection was 45.78±21.05 ng/ml, that different wasn't statistically significant (P=0.1). Serum levels of zinc in patients with acute respiratory infection was 87.93±23.34 μg/dl and in children without infection was 106.95±23.70 μg/dl, the difference was statistically significant (P=0.002). Conclusion: According to finding in this trial, there is a correlation between lower levels of zinc in serum, and chance of respiratory tract infection in children. Future larger studies could provide the correlation between serum levels of vitamins A & D and chance of respiratory tract infection.
- Subjects
EAST (U.S.); VITAMIN A; VITAMIN D; RESPIRATORY infections; ZINC; MICRONUTRIENTS; CHILDREN; INFECTION in children
- Publication
Tehran University Medical Journal, 2014, Vol 71, Issue 12, p794
- ISSN
1683-1764
- Publication type
Article