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- Title
Development of Tropical Spastic Paraparesis in Human T-Lymphotropic Virus Type 1 Carriers Is Influenced by Interleukin 28B Gene Polymorphisms.
- Authors
Treviño, Ana; Lopez, Mariola; Vispo, Eugenia; Aguilera, Antonio; Ramos, Jose M.; Benito, Rafael; Roc, Lourdes; Eiros, Jose M.; de Mendoza, Carmen; Soriano, Vincent
- Abstract
Interleukin 28B (IL28B) polymorphisms were examined in 41 individuals with human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis than in 29 asymptomatic carriers, and median HTLV-1 proviral load was greater with CT/TT than CC. IL28B testing and closer monitoring is warranted in CT/TT carriers.Interleukin 28B (IL28B) rs12979860 polymorphisms were examined in 41 individuals with human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis than in 29 asymptomatic carriers (80% vs 20%; P = .03), and median HTLV-1 proviral load was greater in CT/TT than CC carriers (P = .01). Thus, IL28B testing and closer follow-up of HTLV-1 asymptomatic CT/TT carriers is warranted.
- Subjects
SPASTIC paralysis; PARAPARESIS; HTLV-I; GENETIC polymorphisms; INTERLEUKINS; FOLLOW-up studies (Medicine); GENE frequency
- Publication
Clinical Infectious Diseases, 2012, Vol 55, Issue 1, pe1
- ISSN
1058-4838
- Publication type
Article