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- Title
Plasma choline-containing phospholipids: potential biomarkers for colorectal cancer progression.
- Authors
Li, Song; Guo, Bin; Song, Jianwen; Deng, Xiaoli; Cong, Yusheng; Li, Pengfei; Zhao, Ke; Liu, Lihong; Xiao, Gang; Xu, Feng; Ye, Yingjiang; Zhao, Zhenwen; Yu, Menggang; Xu, Yan; Sang, Jianli; Zhang, Junjie
- Abstract
Colorectal cancer (CRC) is believed to progress through the adenoma-carcinoma sequence. The adenoma-carcinoma transition is an important window for early detection and intervention of CRC. In the present study, plasma samples from patients with CRC ( n = 120), patients with adenomatous polyps (AP) ( n = 120), and healthy controls ( n = 120) were collected. Plasma phospholipid levels were analyzed with liquid chromatography-tandem mass spectrometry. It was found that the plasma levels of major lysophosphatidylcholine (LPC) species were gradationally decreased from healthy controls, AP to CRC subjects. A formula including total saturated LPCs, 18:2 LPC and sphingosylphosphorylcholine (SPC) yielded a sensitivity and specificity of 88.3 and 80 % for separating CRC from healthy controls. An optimized model with total saturated LPCs, 20:4 LPC and sphingomyelins (SM) as markers yielded a sensitivity and specificity of 89 and 80 % for separating AP from the healthy controls. Moreover, with SM, SPC and saturated LPCs as markers, a model was made to separate CRC from AP with the sensitivity and specificity of 90 and 92.5 %, respectively. These data indicate that the plasma choline-containing phospholipid levels represent potential biomarkers to distinguish between healthy controls, AP and CRC cases, implying their clinical usage in CRC and/or AP-CRC progression detection.
- Subjects
COLON cancer; ADENOMATOUS polyps; PHOSPHOLIPIDS; MASS spectrometry; BIOMARKERS; ADENOMA
- Publication
Metabolomics, 2013, Vol 9, Issue 1, p202
- ISSN
1573-3882
- Publication type
Article
- DOI
10.1007/s11306-012-0439-z