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- Title
Anterior cingulate activation in antipsychotic-naïve first-episode schizophrenia.
- Authors
Yücel, M.; Brewer, W. J.; Harrison, B. J.; Fornito, A.; O'Keefe, G. J.; Olver, J.; Scott, A. M.; Egan, G. F.; Velakoulis, D.; McGorry, P. D.; Pantelis, C.
- Abstract
Objective: Anterior cingulate (ACC) hypo-activity is commonly observed in chronically ill schizophrenia patients. However, it is unclear whether this is secondary to persistent illness and/or medication. Method: We examined eight antipsychotic-naïve first-episode patients and matched healthy controls undergoing PET scanning while performing the Stroop task. Results: Group-averaged and single-subject analyses showed ACC activation in both controls and patients, albeit in different sub-regions (paracingulate and cingulate respectively). A direct comparison revealed relative under-activity of the left paracingulate cortex in patients. Conclusion: These findings suggest that the more pervasive hypo-activation observed in chronic patients may be secondary to persistent illness and/or medication.
- Subjects
PSYCHOSES; SCHIZOPHRENIA; PEOPLE with schizophrenia; POSITRON emission tomography; CEREBRAL cortex; ANTIPSYCHOTIC agents; DRUG administration
- Publication
Acta Psychiatrica Scandinavica, 2007, Vol 115, Issue 2, p155
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/j.1600-0447.2006.00902.x