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- Title
The Role of CARD9 Deficiency in Neutrophils.
- Authors
Sheng, Ruanmei; Zhong, Xiaoming; Yang, Zhiwen; Wang, Xuemin
- Abstract
Neutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. Great efforts are underway to better understand the nature of neutrophilic inflammation. Of note, CARD9, a myeloid cell-specific signaling protein that mainly expresses in macrophages and dendritic cells, is also present in neutrophils, emerging as a critical mediator for intercellular communication. CARD9–deficiency neutrophils display an increased susceptibility to fungal infection that primarily localize to the central nervous system, subcutaneous, and skin tissue. Additionally, CARD9–deficiency neutrophils are associated with some autoimmune diseases and even provide protection against a few bacteria. Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils.
- Subjects
NEUTROPHILS; CELL communication; CENTRAL nervous system; DENDRITIC cells; MYCOSES
- Publication
Mediators of Inflammation, 2021, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2021/6643603