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- Title
Mouse polyomavirus large T antigen inhibits cell growth and alters cell and colony morphology in Saccharomyces cerevisiae
- Authors
Adamec, T.; Palková, Z.; Forstová, J.
- Abstract
The gene for mouse polyomavirus large tumor (LT) antigen, a potent oncoprotein, was expressed in Saccharomyces cerevisiae from the inducible GAL1 promoter. Substantial cell growth inhibition as well as colony and cell morphology changes dependent on cyclic adenosine monophosphate (cAMP) were observed. In contrast to cell and colony morphology alterations, the growth inhibition appeared to be transient, thus indicating the existence of an active adaptation of yeast cells to the LT antigen presence.
- Subjects
GENES; POLYOMAVIRUSES; TUMOR antigens; ADENOSINE monophosphate
- Publication
FEBS Letters, 2003, Vol 555, Issue 2, p268
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)01246-8