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- Title
NF-κB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6
- Authors
Kanamori, Mutsumi; Kai, Chikatoshi; Hayashizaki, Yoshihide; Suzuki, Harukazu
- Abstract
NF-κB activator 1 (Act1), also called CIKS, is a recently identified protein with NF-κB and AP-1 activation activities through its association with the IκB kinase complex. We identified and confirmed that Act1 interacts with tumor necrosis factor receptor-associated factor 6 (TRAF6); notably, Act1 binds to TRAF6 only among TRAF family proteins. The amino-terminal half of Act1 is required for its interaction with the TRAF domain. Act1-mediated NF-κB activation was inhibited by a dominant-negative mutant of TRAF6 in a dose-dependent manner, and IL-1-induced NF-κB activation was inhibited by a high level of Act1 expression. Our results suggest that Act1 is involved in IL-1/Toll-mediated signaling through TRAF6.
- Subjects
NF-kappa B; TUMOR necrosis factors
- Publication
FEBS Letters, 2002, Vol 532, Issue 1/2, p241
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)03688-8