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- Title
Identification of a novel RNA silencing suppressor, NSs protein of Tomato spotted wilt virus
- Authors
Takeda, Atsushi; Sugiyama, Kazuhiko; Nagano, Hideaki; Mori, Masashi; Kaido, Masanori; Mise, Kazuyuki; Tsuda, Shinya; Okuno, Tetsuro
- Abstract
RNA silencing or post-transcriptional gene silencing (PTGS) in plants is known as a defense system against virus infection. Several plant viruses have been shown to encode an RNA silencing suppressor. Using a green fluorescent protein-based transient suppression assay, we show that NSs protein of Tomato spotted wilt virus (TSWV) has RNA silencing suppressor activity. TSWV NSs protein suppressed sense transgene-induced PTGS but did not suppress inverted repeat transgene-induced PTGS. TSWV NSs protein is the first RNA silencing suppressor identified in negative-strand RNA viruses.
- Subjects
GENE silencing; PLANT viruses
- Publication
FEBS Letters, 2002, Vol 532, Issue 1/2, p75
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)03632-3