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- Title
Risk factors for infection with Campylobacter jejuni flaA genotypes.
- Authors
Unicomb LE; O'Reilly LC; Kirk MD; Stafford RJ; Smith HV; Becker NG; Patel MS; Gilbert GL; Australian Campylobacter Subtyping Study Group; Unicomb, L E; O'Reilly, L C; Kirk, M D; Stafford, R J; Smith, H V; Becker, N G; Patel, M S; Gilbert, G L
- Abstract
We aimed to explore Campylobacter genotype-specific risk factors in Australia. Isolates collected prospectively from cases recruited into a case-control study were genotyped using flaA restriction fragment-length polymorphism typing (flaA genotyping). Exposure information for cases and controls was collected by telephone interview. Risk factors were examined for major flaA genotypes using logistic and multinomial regression. Five flaA genotypes accounted for 325 of 590 (55%) cases - flaA-6b (n=129), flaA-6 (n=70), flaA-10 (n=48), flaA-2 (n=43), flaA-131 (n=35). In Australia, infections due to flaA-10 and flaA-2 were found to be significantly associated with eating non-poultry meat (beef and ham, respectively) in both case-control and inter-genotype comparisons. All major genotypes apart from flaA-10 were associated with chicken consumption in the case-control comparisons. Based on several clinical criteria, infections due to flaA-2 were more severe than those due to other genotypes. Thus genotype analysis may reveal genotype-specific niches and differences in virulence and transmission routes.
- Publication
Epidemiology & Infection, 2008, Vol 136, Issue 11, p1480
- ISSN
0950-2688
- Publication type
journal article
- DOI
10.1017/S0950268807000246