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- Title
Smoking and polymorphisms of fucosyltransferase gene Le affect success of H. pylori eradication with lansoprazole, amoxicillin, and clarithromycin.
- Authors
K. MATSUO; N. HAMAJIMA; Y. IKEHARA; T. SUZUKI; T. NAKAMURA; A. MATSUURA; K. TAJIMA; S. TOMINAGA
- Abstract
Identification of factors influencing success of Helicobacter pylori (HP) eradication is important for clinical practice. We have prospectively conducted an HP eradication study in the Aichi Cancer Center with a total of 142 patients available for analysis. The overall success rate was 61·3% (95% confidence interval 52·769·3%). Smoking during the medication for eradication significantly decreased the success rate (42·9%), whereas smoking cessation during the treatment was associated with a similar rate as for non-smokers (66·7%). We also examined links between an eradication outcome and polymorphisms of Le, Se, IL1A, IL1B, IL1RN and MPO genes, but with one exception none showed any association. The non-functional le allele of Le polymorphisms, leading to decreased expression of Leb antigen to which HP attaches with adhesin, showed a beneficial effect for success. Although further clarification is necessary, our study indicated that smoking cessation and Le gene polymorphisms may affect the success rate of HP eradication.
- Subjects
HELICOBACTER pylori; CLINICAL medicine; GENETIC polymorphisms; SMOKING cessation; NICOTINE addiction treatment
- Publication
Epidemiology & Infection, 2003, Vol 130, Issue 2, p227
- ISSN
0950-2688
- Publication type
Article
- DOI
10.1017/s0950268802008129