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- Title
The implications of amyloid-β pathology: only time will tell.
- Authors
Coomans, Emma M; Ossenkoppele, Rik
- Abstract
This scientific commentary discusses the implications of amyloid-β pathology in Alzheimer's disease. The amyloid cascade hypothesis suggests that the deposition of amyloid-β in the brain leads to downstream events, including the aggregation of tau protein, synaptic dysfunction, neuronal loss, and cognitive impairment. However, amyloid-β deposition can occur years before cognitive symptoms appear, making it challenging to study the trajectory of amyloid-β and its relationship with tau accumulation. The study by Cody et al. estimates the age at which amyloid-β becomes abnormal for each participant and explores the associations between amyloid-β, tau accumulation, and cognitive decline. The findings suggest that the first decade after amyloid-β onset is a critical time window for intervention. However, further research is needed to validate these findings and compare different measurement methods.
- Subjects
CEREBRAL amyloid angiopathy; PATHOLOGY; ALZHEIMER'S disease
- Publication
Brain: A Journal of Neurology, 2024, Vol 147, Issue 6, p1934
- ISSN
0006-8950
- Publication type
Article
- DOI
10.1093/brain/awae147