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- Title
BMP5/7 protect dopaminergic neurons in an α-synuclein mouse model of Parkinson's disease.
- Authors
Vitic, Zagorka; Safory, Hazem; Jovanovic, Vukasin M; Sarusi, Yael; Stavsky, Alexandra; Kahn, Joy; Kuzmina, Alona; Toker, Lilah; Gitler, Daniel; Taube, Ran; Friedel, Roland H; Engelender, Simone; Brodski, Claude
- Abstract
BMP5/7 are not only essential for the development of DA neurons, but BMP7 also shows beneficial effects in a toxin-based Parkinson's disease animal model (Zuch et al., 2004). LETTER TOTHE EDITOR BMP5/7 protect dopaminergic neurons in an a-synuclein mouse model of Parkinson's disease ZagorkaVitic, 1 HazemSafory, 2 VukasinM. In contrast to toxin-induced DA neurodegeneration, GDNF does not protect substantia nigra neurons against asynuclein-induced DA neurodegeneration in a rat Parkinson's disease model (Decressac et al.,2012). BMP5/7 protect dopaminergic neurons in an -synuclein mouse model of Parkinson's disease.
- Subjects
PARKINSON'S disease; DOPAMINERGIC neurons; SUBTHALAMIC nucleus; GLIAL cell line-derived neurotrophic factor; NEURAL stem cells; BIOLOGICAL models; NERVE tissue proteins; NEURONS; MICE; BRAIN stem; ANIMALS
- Publication
Brain: A Journal of Neurology, 2021, Vol 144, Issue 2, pe15
- ISSN
0006-8950
- Publication type
letter
- DOI
10.1093/brain/awaa368