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- Title
Effect of Telmisartan on Post-Challenge Insulin Response in Japanese Obese Patients with Hypertension.
- Authors
Itoh, Yohta; Mori, Yutaka; Tajima, Naoko
- Abstract
The angiotensin receptor blockers (ARBs) are reported to be insulin-sensitizers, and telmisartan is also reported in in vitro or animal studies as well as in clinical studies to have PPAR-γ-mediated insulin-sensitizing properties, unlike the other ARBs. In this study, telmisartan was examined for its effects on post-glucose challenge insulin response in hypertensive patients with obesity when they were switched from the other ARBs. Of the 22 hypertensive patients with BMI ≥ 25 being treated with ARBs other than telmisartan at our outpatient clinic, 14 patients who agreed to switch to telmiartan (TS group) were compared to 8 patients who stayed on the other ARBs (non-TS group). Patients were excluded if they were receiving oral hypoglycemic agents or insulin for diabetes mellitus (DM); if they had their blood pressure poorly controlled during the observation period; or if they switched their drug therapies. At baseline, 1 patient each was found to have NGT and IFG and 3 patients each were to have IGT and DM in the non-TS group, while 3, 1, 6 and 4 patients were found to have NGT, IFG, IGT and DM, respectively, in the TS group. BMI values in the TS and non-TS groups were 28.3 ± 3.4 and 26.3 ± 1.6, respectively. HbA1c values in the TS and non-TS groups were 5.6 ± 0.6 and 5.8 ± 0.5, respectively. There were no significant differences in all variables evaluated in the non-TS group at the end of the study compared to baseline. In contrast, TG values were found to be significantly lower, and HDL-C values significantly higher, in the TS group compared to baseline, while there were no significant differences noted in BMI, HbA1c and TC values. Furthermore, the 120-minute post-75 g OGTT glucose level and the area under the glucose curve 6 months after the start of treatment were significantly lower in the TS group compared to baseline, with the 60-, 90- and 180-minute post-challenge insulin levels and area under the insulin curve also significantly lower compared to baseline. It was suggested that telmisartan has a more favorable impact on insulin sensitization in hypertensive patients with obesity than the other ARBs.
- Subjects
HYPOGLYCEMIC agents; INSULIN; BLOOD sugar; HYPERTENSION; OBESITY; JAPANESE people; DIABETES; BLOOD pressure; DISEASES
- Publication
Diabetes, 2007, Vol 56, pA578
- ISSN
0012-1797
- Publication type
Article