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- Title
Synthesis and Characterization of Ligand-Stabilized Silver Nanoparticles and Comparative Antibacterial Activity against E. coli.
- Authors
Egodawaththa, Nishal M.; Knight, Amy L.; Ma, Jingxuan; Knight, D. Andrew; Guisbert, Eric; Nesnas, Nasri
- Abstract
Silver is a well-established antimicrobial agent. Conjugation of organic ligands with silver nanoparticles has been shown to create antimicrobial nanoparticles with improved pharmacodynamic properties and reduced toxicity. Twelve novel organic ligand functionalized silver nanoparticles (AgNPs) were prepared via a light-controlled reaction with derivatives of benzothiazole, benzoxazine, quinazolinone, 2-butyne-1,4-diol, 3-butyne-1-ol, and heptane-1,7-dioic. UV-vis, Fourier-transform infrared (FTIR) spectroscopy, and energy-dispersive X-ray (EDAX) analysis were used to confirm the successful formation of ligand-functionalized nanoparticles. Dynamic light scattering (DLS) revealed mean nanoparticle diameters between 25 and 278 nm. Spherical and nanotube-like morphologies were observed using transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Seven of the twelve nanoparticles exhibited strong antimicrobial activity and five of the twelve demonstrated significant antibacterial capabilities against E. coli in a zone-of-inhibition assay. The synthesis of functionalized silver nanoparticles such as the twelve presented is critical for the further development of silver-nanoconjugated antibacterial agents.
- Subjects
ESCHERICHIA coli; SILVER nanoparticles; BENZOXAZINES; ANTIBACTERIAL agents; TRANSMISSION electron microscopy; NANOPARTICLES; NANOPARTICLES analysis
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 23, p15251
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232315251