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- Title
TRPV4 Promotes Metastasis in Melanoma by Regulating Cell Motility through Cytoskeletal Rearrangement.
- Authors
Huang, Shuai; Yu, Suyun; Deng, Rui; Liu, Huan; Ding, Yushi; Sun, Yifan; Chen, Wenxing; Wang, Aiyun; Wei, Zhonghong; Lu, Yin
- Abstract
The abnormal expression of Transient Receptor Potential cation channel subfamily V member 4 (TRPV4) is closely related to the progression of multiple tumors. In addition, TRPV4 is increasingly being considered a potential target for cancer therapy, especially in tumor metastasis prevention. However, the biological correlation between TRPV4 and tumor metastasis, as well as the specific role of TRPV4 in malignant melanoma metastasis, is poorly understood. In this study, we aimed to examine the role of TRPV4 in melanoma metastasis through experiments and clinical data analysis, and the underlying anticancer mechanism of Baicalin, a natural compound, and its inhibitory effect on TRPV4 with in vivo and in vitro experiments. Our findings suggested that TRPV4 promotes metastasis in melanoma by regulating cell motility via rearranging the cytoskeletal, and Baicalin can inhibit cancer metastasis, whose mechanisms reverse the recruitment of activated cofilin to leading-edge protrusion and the increasing phosphorylation level of cortactin, which is provoked by TRPV4 activation.
- Subjects
TRP channels; TRPV cation channels; CELL motility
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 23, p15155
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232315155