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- Title
A DIFFUSE T LYMPHOCYTIC GASTROINTESTINAL MUCOSAL INFILTRATION ASSOCIATED WITH SJÖGREN'S SYNDROME RESULTING IN A WATERY DIARRHEA SYNDROME AND RESPONSIVE TO IMMUNOSUPPRESSIVE THERAPY.
- Authors
Sobhani, Iradj; Brousse, Nicole; Vissuzaine, Christiane; Mcintyre, Elisabeth; Marmuse, Jean Pierre; Kahn, Marcel Francis; Potet, François; Mignon, Michel
- Abstract
We report the case of a 45-yr-old white man, investigated for chronic diarrhea, malabsorption and weight loss associated with sicca syndrome. Endoscopic and x-ray examinations showed normal macroscopic mucosa in gastrointestinal tract (GIT). Immunohistochemistry showed diffuse polyclonal T cell lymphocytes infiltrating either epithelium and lamina propria in GIT. There was no villous atrophy in the Jejunum and ileum. Corticosteroids, azathioprine, and cyclosporine failed to improve symptoms. Monthly intravenous ciclophosphamide administered over 1 yr, stopped the diarrhea and weight loss. The patient is free of symptoms up to a 5-yr follow-up.
- Subjects
DIARRHEA in old age; WEIGHT loss; SJOGREN'S syndrome; MUCOUS membranes; GASTROINTESTINAL system
- Publication
American Journal of Gastroenterology (Springer Nature), 1998, Vol 93, Issue 12, p2584
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.1998.00724.x