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- Title
Acute Neurological Involvement after Donor Lymphocyte Infusion for Post-Transplant Viral Infection: The Same Pattern of Novel Cancer Immunotherapy-Related CNS Toxicity?
- Authors
Marcuzzi, Annalisa; Rimondi, Erika; Melloni, Elisabetta; Zennaro, Floriana; Sonzogni, Aurelio; Leo, Sara; Maximova, Natalia
- Abstract
Early post-transplant is the critical phase for the success of hematopoietic stem cell transplantation (HSCT). New viral infections and the reactivations associated with complete ablation of the recipient's T-cell immunity and inefficient reconstitution of the donor-derived system represent the main risks of HSCT. To date, the pharmacological treatments for post-HSCT viral infection-related complications have many limitations. Adoptive cell therapy (ACT) represents a new pharmacological strategy, allowing us to reconstitute the immune response to infectious agents in the post-HSC period. To demonstrate the potential advantage of this novel immunotherapy strategy, we report three cases of pediatric patients and the respective central nervous system complications after donor lymphocyte infusion.
- Subjects
HEMATOPOIETIC stem cell transplantation; LYMPHOCYTES; CENTRAL nervous system; VIRUS diseases; CELLULAR therapy; VIRUS reactivation
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 7, p3553
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23073553