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- Title
Cancer-Associated Adipocytes in Breast Cancer: Causes and Consequences.
- Authors
Rybinska, Ilona; Mangano, Nunzia; Tagliabue, Elda; Triulzi, Tiziana; Rosado, Juan A.
- Abstract
Breast cancer progression is highly dependent on the heterotypic interaction between tumor cells and stromal cells of the tumor microenvironment. Cancer-associated adipocytes (CAAs) are emerging as breast cancer cell partners favoring proliferation, invasion, and metastasis. This article discussed the intersection between extracellular signals and the transcriptional cascade that regulates adipocyte differentiation in order to appreciate the molecular pathways that have been described to drive adipocyte dedifferentiation. Moreover, recent studies on the mechanisms through which CAAs affect the progression of breast cancer were reviewed, including adipokine regulation, metabolic reprogramming, extracellular matrix remodeling, and immune cell modulation. An in-depth understanding of the complex vicious cycle between CAAs and breast cancer cells is crucial for designing novel strategies for new therapeutic interventions.
- Subjects
BREAST cancer; ETIOLOGY of cancer; FAT cells; EXTRACELLULAR matrix; STROMAL cells; ADIPOGENESIS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 7, p3775
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22073775