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- Title
A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy.
- Authors
Chen, Lili; Fujisawa, Nanami; Takanohashi, Masato; Najmina, Mazaya; Uto, Koichiro; Ebara, Mitsuhiro; Quiles, José L.
- Abstract
This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(ε-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery.
- Subjects
DOXORUBICIN; FEVER; CANCER treatment; MAGNETIC nanoparticles; HEAT shock proteins
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 5, p2542
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22052542