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- Title
Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies.
- Authors
Daams, Renée; Massoumi, Ramin
- Abstract
The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase. Very recently, NLK was established as an essential regulator in different cellular processes and abnormal NLK expression was highlighted to affect the development and progression of various diseases. In this review, we focused on the recent discoveries by using NLK-deficient mice, which show a phenotype in the development and function of organs such as the lung, heart and skeleton. Furthermore, NLK could conduct the function and differentiation of cells from the immune system, in addition to regulating neurodegenerative diseases, such as Huntington's disease and spinocerebellar ataxias. Overall, generations of NLK-deficient mice have taught us valuable lessons about the role of this kinase in certain diseases and development.
- Subjects
HUNTINGTON disease; MORPHOGENESIS; CELL differentiation; WNT signal transduction; CELL polarity; SKELETON
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 23, p9203
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21239203