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- Title
Insights into the Role of Bioactive Food Ingredients and the Microbiome in Idiopathic Pulmonary Fibrosis.
- Authors
Mercader-Barceló, Josep; Truyols-Vives, Joan; Río, Carlos; López-Safont, Nora; Sala-Llinàs, Ernest; Chaplin, Alice
- Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic disease mainly associated with aging and, to date, its causes are still largely unknown. It has been shown that dietary habits can accelerate or delay the occurrence of aging-related diseases; however, their potential role in IPF development has been underestimated so far. The present review summarizes the evidence regarding the relationship between diet and IPF in humans, and in animal models of pulmonary fibrosis, in which we discuss the bioactivity of specific dietary food ingredients, including fatty acids, peptides, amino acids, carbohydrates, vitamins, minerals and phytochemicals. Interestingly, many animal studies reveal preventive and therapeutic effects of particular compounds. Furthermore, it has been recently suggested that the lung and gut microbiota could be involved in IPF, a relationship which may be linked to changes in immunological and inflammatory factors. Thus, all the evidence so far puts forward the idea that the gut-lung axis could be modulated by dietary factors, which in turn have an influence on IPF development. Overall, the data reviewed here support the notion of identifying food ingredients with potential benefits in IPF, with the ultimate aim of designing nutritional approaches as an adjuvant therapeutic strategy.
- Subjects
IDIOPATHIC pulmonary fibrosis; FOOD habits; PULMONARY fibrosis; TREATMENT effectiveness; CARBOHYDRATE content of food; GUT microbiome; ALCOHOLS (Chemical class)
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 17, p6051
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21176051