We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Non-Coding RNAs as Key Regulators of Glutaminolysis in Cancer.
- Authors
Ortiz-Pedraza, Yunuen; Muñoz-Bello, J. Omar; Olmedo-Nieva, Leslie; Contreras-Paredes, Adriana; Martínez-Ramírez, Imelda; Langley, Elizabeth; Lizano, Marcela
- Abstract
Cancer cells exhibit exacerbated metabolic activity to maintain their accelerated proliferation and microenvironmental adaptation in order to survive under nutrient-deficient conditions. Tumors display an increase in glycolysis, glutaminolysis and fatty acid biosynthesis, which provide their energy source. Glutamine is critical for fundamental cellular processes, where intermediate metabolites produced through glutaminolysis are necessary for the maintenance of mitochondrial metabolism. These include antioxidants to remove reactive oxygen species, and the generation of the nonessential amino acids, purines, pyrimidines and fatty acids required for cellular replication and the activation of cell signaling. Some cancer cells are highly dependent on glutamine consumption since its catabolism provides an anaplerotic pathway to feed the Krebs cycle. Intermediate members of the glutaminolysis pathway have been found to be deregulated in several types of cancers and have been proposed as therapeutic targets and prognostic biomarkers. This review summarizes the main players in the glutaminolysis pathway, how they have been found to be deregulated in cancer and their implications for cancer maintenance. Furthermore, non-coding RNAs are now recognized as new participants in the regulation of glutaminolysis; therefore, their involvement in glutamine metabolism in cancer is discussed in detail.
- Subjects
KREBS cycle; AMINO acids; FATTY acids; CANCER; CANCER cells; NON-coding RNA; GLUTAMINE synthetase
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 8, p2872
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21082872