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- Title
A legume product fermented by Saccharomyces cerevisiae modulates cutaneous atopic dermatitislike inflammation in mice.
- Authors
Chiou-Yueh Yeh; Chiau-Jing Jung; Ching-Ning Huang; Ying-Che Huang; Huei-Ting Lien; Won-Bo Wang; Li-Fang Wang; Jean-San Chia
- Abstract
Background Isoflavone-containing soy products modulate allergic inflammation in mice. In our previously study, IFN-γ and IL-10 production increased in mice fed with Saccharomyces cerevisiae legume fermented product (SCLFP), demonstrating that SCLFP had immunomodulatory activity. In this study, we tested the anti-inflammatory effects of SCLFP in a mouse model of cutaneous atopic dermatitis inflammation induced by epicutaneous sensitization. Methods Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. The thickness of the skin epithelium, eosinophil migration, and T helper responses were determined in patched skin and draining lymph nodes of mice fed with and without SCLFP. Results Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. SCLFP feeding attenuated this cutaneous Th2 response, as evidenced by decreased thickening of the epidermis, less eosinophil infiltration, and lower levels of IL-5, IL-13, and CXCL11 expression compared to controls. Oral administration of SCLFP also modulated Th1 responses in draining lymph nodes, with lower levels of IFN-γ, IL-4, and IL-17 expression. Conclusion Oral intake of SCLFP modulated the induced Th2 inflammatory responses in skin and might have potential applications for the prevention and treatment of atopic dermatitis.
- Subjects
ANALYSIS of variance; ANIMAL experimentation; ATOPIC dermatitis; FERMENTATION; INFLAMMATORY mediators; LEGUMES; MICE; RESEARCH funding; STATISTICS; YEAST; DATA analysis; DESCRIPTIVE statistics; PHARMACODYNAMICS
- Publication
BMC Complementary & Alternative Medicine, 2014, Vol 14, Issue 1, p1
- ISSN
1472-6882
- Publication type
Article
- DOI
10.1186/1472-6882-14-194