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- Title
Virus membrane-fusion proteins: more than one way to make a hairpin.
- Authors
Kielian, Margaret; Rey, Félix A.
- Abstract
Structure–function studies have defined two classes of viral membrane-fusion proteins that have radically different architectures but adopt a similar overall 'hairpin' conformation to induce fusion of the viral and cellular membranes and therefore initiate infection. In both classes, the hairpin conformation is achieved after a conformational change is triggered by interaction with the target cell. This review will focus in particular on the properties of the more recently described class II proteins.
- Subjects
MEMBRANE fusion; CELL adhesion; VIRAL envelopes; CELL membranes; PROTEINS; BIOLOGICAL membranes; MICROBIOLOGY
- Publication
Nature Reviews Microbiology, 2006, Vol 4, Issue 1, p67
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro1326