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- Title
Cerebral phaeohyphomycosis caused by Fonsecaea monophora.
- Authors
Surash, S.; Tyagi, A.; De Hoog, G. S.; Zeng, J.-S.; Barton, R. C.; Hobson, R. P.
- Abstract
We report a case of cerebral phaeohyphomycosis in a 53-year-old immunocompetent diabetic male, caused by Fonsecaea monophora . Computerized tomography of the brain revealed an abscess, which yielded F. monophora in pure culture. The patient's condition deteriorated on treatment with voriconazole and 5-fluorocytosine, and improved subsequently with high-dose itraconazole. The genus Fonsecaea has recently been revised and the new species F. monophora generated from molecular analysis of isolates, most of which were originally identified as Fonsecaea pedrosoi . This is the fourth case of cerebral infection known to have been caused by F. monophora , although only the first reported as such. These cases suggest that the clinical potential of F. monophora differs from that of F. pedrosoi , one of the main agents of chromoblastomycosis, with F. monophora being predominantly neurotropic in the human host.
- Subjects
MYCOSES; FUNGI; INFECTION; BRAIN; CELL culture
- Publication
Medical Mycology, 2005, Vol 43, Issue 5, p465
- ISSN
1369-3786
- Publication type
Article
- DOI
10.1080/13693780500220373