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- Title
Aldosterone, SGK1, and ion channels in the kidney.
- Authors
Valinsky, William C.; Touyz, Rhian M.; Shrier, Alvin
- Abstract
Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na+, K+, and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is an active transcriptional modifier when bound to the mineralocorticoid receptor (MR) in cells expressing the enzyme 11ß-hydroxysteroid dehydrogenase 2, such as those comprising the aldosterone-sensitive distal nephron (ASDN). One such up-regulated protein, the ubiquitous serum and glucocorticoid regulated kinase 1 (SGK1), has the capacity to modulate the surface expression and function of many classes of renal ion channels, including those that transport Na+ (ENaC), K+ (ROMK/BK), Ca2+ (TRPV4/5/6), Mg2+ (TRPM7/6), and Cl-(ClC-K, CFTR). Here, we discuss the mechanisms by which ASDN expressed channels are up-regulated by SGK1, while highlighting newly discovered pathways connecting aldosterone to nonselective cation channels that are permeable to Mg2+ (TRPM7) or Ca2+ (TRPV4).
- Subjects
HYPERALDOSTERONISM; ALDOSTERONE; SGK protein; ION channels; KIDNEY function tests; MINERALOCORTICOID receptors
- Publication
Clinical Science, 2018, Vol 132, Issue 2, p173
- ISSN
0143-5221
- Publication type
Article
- DOI
10.1042/CS20171525