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- Title
Ligand-Controlled Palladium-Catalyzed Pyridylation of 1- tert-Butoxycarbonyl-3-iodoazetidine: Regioselective Synthesis of 2- and 3-Heteroarylazetidines.
- Authors
Zhang, Yudan; Geng, Zhiyue; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
- Abstract
The first efficient regioselective pyridylation of 1- tert-butoxycarbonyl-3-iodoazetidine to produce 2- and 3-heteroarylazetidines under palladium-catalyzed conditions has been developed. The established direct pyridylation of azetidines affords 2- vs. 3-heteroarylazetidines in moderate to good yields (up to 92%) and with good regioselectivity (up to 98:2) by using different ligands.
- Subjects
PALLADIUM catalysts; REGIOSELECTIVITY (Chemistry); LIGAND exchange reactions; COORDINATION compounds; CHEMICAL synthesis
- Publication
Advanced Synthesis & Catalysis, 2017, Vol 359, Issue 3, p390
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201600470