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- Title
Palladium-Catalyzed Stereospecific Allylation of Nitroacetates with Enantioenriched Primary Allylic Amines.
- Authors
Xu, Jing ‐ Kun; Wang, Yong; Gu, Yonghong; Tian, Shi ‐ Kai
- Abstract
An unprecedented stereospecific allylation reaction of nitroacetates with enantioenriched primary allylic amines has been developed. A range of nitroacetates smoothly underwent allylation with enantioenriched primary allylic amines in the presence of a palladium catalyst and boric acid followed by one-pot decarboxylation to afford structurally diverse homoallylic nitro compounds in good to excellent yields with excellent retention of configuration. On the other hand, the allylation followed by denitronation provided a facile synthetic route to optically active β-chiral γ,δ-unsaturated esters.
- Subjects
PALLADIUM; ALLYLATION; ACETATES; ALLYLIC amination; BORIC acid
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 11, p1854
- ISSN
1615-4150
- Publication type
Other
- DOI
10.1002/adsc.201600059