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- Title
Outcomes of hypertrophic cardiomyopathy in Japanese children: a retrospective cohort study.
- Authors
Mori, Hiroki; Yoshikawa, Tadahiro; Kimura, Hitomi; Ono, Hiroshi; Kato, Hitoshi; Ono, Yasuo; Nii, Masaki; Shindo, Takahiro; Inuzuka, Ryo; Horigome, Hitoshi; Miura, Masaru; Hirono, Keiichi; Kobayashi, Tomio; Kogaki, Shigetoyo; Furutani, Yoshiyuki; Nakanishi, Toshio
- Abstract
There has been no multicenter study on the prognosis of pediatric hypertrophic cardiomyopathy (HCM) in Japan. Therefore, we conducted a retrospective multicenter observational study on the long-term survival rate in patients diagnosed with HCM under the age of 18 between 1990 and 2014. Twenty institutions participated. A total of 180 patients were identified. The median age at diagnosis was 5.8 years old and median duration of observation was 8.3 years. Although six patients (3%) deteriorated into the dilated phase of HCM, no patient received heart transplantation. Freedom from death at 1, 5, 10, and 20 years were 97%, 92%, 84%, and 80%, respectively. There were 26 deaths. Among them, 11 patients died suddenly, presumably due to arrhythmia, and 15 patients died of heart failure. The presence of heart failure symptoms and a greater cardiothoracic ratio were significant risk factors for heart failure-related death. There were no significant risk factors identified for arrhythmia-related death. In conclusion, the prognosis of pediatric HCM in Japan is good and similar to those reported in population-based studies in the United States and Australia. Significant risk factors for heart failure-related death were identified in pediatric patients with HCM in Japan.
- Subjects
JAPAN; HYPERTROPHIC cardiomyopathy; JAPANESE people; HEART failure; HEART transplant recipients; CHILD patients; COHORT analysis
- Publication
Heart & Vessels, 2022, Vol 37, Issue 6, p1075
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-021-01989-7