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- Title
Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis.
- Authors
Yu, Tao; Du, Yingxiang; Chen, Jiaquan; Xu, Guangfu; Yang, Ke; Zhang, Qi; Zhang, Jinjing; Du, Shuaijing; Feng, Zijie; Zhang, Yanjie
- Abstract
In this paper, the use of clarithromycin lactobionate, a kind of antibiotic chiral selector, in combination with four neutral cyclodextrin derivatives (glucose-β-cyclodextrin, hydroxyethyl-β-cyclodextrin, methyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin) was reported for the first time. As a result, these dual systems gave much better resolution of nefopam (the Rs increased to 3.58, 2.72, 1.49 and 1.42, respectively) compared to the single systems. The effects of buffer pH and selector concentration on the separation of nefopam were also investigated. Additionally, some other basic drugs including metoprolol, atenolol, propranolol, bisoprolol, esmolol and ritodrine were tested for the investigation and evaluation of the enantiorecognition capability of the four dual systems. As expected, the synergistic effect was observed in four systems. Different results of these dual systems were also summarized.
- Subjects
CAPILLARY electrophoresis; CYCLODEXTRINS; CLARITHROMYCIN; LACTOBIONIC acid; CHIRALITY; ENANTIOMERS; DRUGS
- Publication
Journal of Separation Science, 2015, Vol 38, Issue 16, p2900
- ISSN
1615-9306
- Publication type
Article
- DOI
10.1002/jssc.201400677