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- Title
White matter disintegration in cluster headache.
- Authors
Szabó, Nikoletta; Kincses, Zsigmond Tamás; Párdutz, Árpád; Tóth, Eszter; Szok, Délia; Csete, Gergő; Vécsei, László
- Abstract
Background: Previous studies in primary headache disorders showed microstructural alterations in the white matter as measured by diffusion imaging. However these investigations are not in full agreement, some of those, especially in cluster headache, restricted the analysis to only a limited number of diffusion parameters. Therefore, in the current study we examined white matter microstructure in cluster headache patients. Methods: Diffusion weighted MRI images with 60 directions were acquired from thirteen patients with cluster headache, sixteen age-matched healthy controls. Tract based spatial statistics were used to compare white matter integrity in the core of the fibre bundles. Correlation of the diffusion parameters with cumulative number of headache days was examined. Results: There was a significant increment of the mean, axial, perpendicular diffusivity in widespread white matter regions in the frontal, parietal, temporal, occipital lobes. Reduced fractional anisotropy was found in the corpus callosum, some frontal, parietal white matter tracts mainly in the contralateral side of the pain. Axial diffusivity showed negative correlation to the number of the headache attacks. Conclusions: The in vivo analysis of microstructural alterations in cluster headache provides important features of the disease, which might offer a deeper insight into the pathomechanism of the disease.
- Publication
Journal of Headache & Pain, 2013, Vol 14, Issue 1, p1
- ISSN
1129-2369
- Publication type
Article
- DOI
10.1186/1129-2377-14-64