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- Title
Novel Sesquiterpenes from Ligularia virgaurea spp. oligocephala.
- Authors
Xia Liu; Quan-Xiang Wu; Xiao-Ning Wei; Yan-Ping Shi
- Abstract
Two novel sesquiterpene dimers, ligularin A (1) and ligulolide D (2), and one new sesquiterpenoid, 1β,10α-dihydroxy-6β-[(2-methylpropyl)oxy]furanoeremophil-9-one (3), as well as two known sesquiterpenoids, 6β-[(2-methylpropyl)oxy]-furanoeremophil-1(10)-en-9-one (4) and 1-hydroxy-3,7-dimethyl-2-(pent-3-enyl)benzofuran (5), were isolated from the petroleum-ether fraction from an alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala. Their structures were elucidated by 1D and 2D-NMR spectroscopy together with HR-ESI-MS analysis, and comparison of the spectroscopic data with those reported for structurally related compounds. In addition, the cytotoxicities against human gastric cancer SGC-7910 cell were measured in vitro, the results demonstrated that these sesquiterpenes have no cytotoxicity against the selected tumor cell (all IC50 values >200 4;μM).
- Subjects
SESQUITERPENES; DIMERS; EXTRACTS; ANTINEOPLASTIC agents
- Publication
Helvetica Chimica Acta, 2007, Vol 90, Issue 9, p1802
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.200790189