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- Title
Single-session photodynamic therapy combined with intravitreal ranibizumab for neovascular age-related macular degeneration: a comprehensive functional retinal assessment.
- Authors
Parravano, Mariacristina; Parisi, Vincenzo; Ziccardi, Lucia; Chiaravalloti, Adele; Tedeschi, Massimiliano; Cacciamani, Andrea; Boccassini, Barbara; Boninfante, Antonluca; Varano, Monica
- Abstract
Purpose: To explore functional retinal changes in neovascular AMD patients (nAMD) treated with ranibizumab 0.5 mg combined with photodynamic therapy (PDT) 3 days after the first injection in the long term. Methods: Patients with no prior treatment for nAMD were treated with 3 injections of ranibizumab 0.5 mg 1 month apart and a single session of standard PDT 3 days after the first injection. Best-corrected visual acuity and time-domain OCT at baseline and every 28 ± 2 days were performed; microperimetry at 3, 6, and 12 months and multifocal electroretinogramm (mfERG) at 3 and 12 months were repeated. Fluorescein angiography and vision-related quality-of-life questionnaire were performed at baseline and 12 months. Results: 12/15 nAMD patients completed the 12 months study and received an average of 3.4 ± 0.7 injections. Mean VA changed from 54.67 ± 15.72 to 59.0 ± 24.77 letters ( p = 0.371), while mean retinal sensitivity from 5.5 ± 4.8 to 6.6 ± 6.0 dB ( p = 0.216). MfERG N1-P1 response amplitude densities (RADs) were significantly different from baseline ( p < 0.01) in the central 0°-2.5°, whereas in the peripheral retinal areas (2.5°-20°), not significant ( p > 0.01) changes in N1-P1 RADs were detected. The 'general vision' VFQ-25 subscale showed a statistically significant improvement at 3 and 12 months. Conclusions: Ranibizumab 0.5 mg combined with standard PDT 3 days after the first injection determines an improvement of mfERG values in the retinal central area in nAMD patients in long-term follow-up.
- Subjects
AGE factors in retinal degeneration; RETINAL degeneration treatment; PHOTODYNAMIC therapy; LUCENTIS (Drug); FUNCTIONAL assessment; PERIMETRY; ELECTRORETINOGRAPHY
- Publication
Documenta Ophthalmologica, 2013, Vol 127, Issue 3, p217
- ISSN
0012-4486
- Publication type
Article
- DOI
10.1007/s10633-013-9404-z