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- Title
Effects of green tea extract supplementation and endurance training on irisin, pro-inflammatory cytokines, and adiponectin concentrations in overweight middle-aged men.
- Authors
Bagheri, Reza; Rashidlamir, Amir; Ashtary-Larky, Damoon; Wong, Alexei; Grubbs, Brandon; Motevalli, Mohamad S.; Baker, Julien S.; Laher, Ismail; Zouhal, Hassane
- Abstract
<bold>Purpose: </bold>Green tea extract (GTE) supplementation has been proposed to possess anti-inflammatory properties. This study assessed the effects of GTE on endurance training (ET) induced changes on irisin, pro-inflammatory cytokines, adiponectin and anthropometric indices in overweight middle-aged males.<bold>Methods: </bold>Participants were randomly assigned to three groups (n = 15): endurance training + placebo (ET + P), endurance training + green tea extract supplementation (ET + GTE), and no endurance training + placebo (P). The ET intervention consisted of an 8-week training program that included circuit training, fast walking or jogging performed three times/week at a moderate intensity (40-59% of the heart rate reserve). Participants received 500 mg/day GTE using a green tea capsule. Serum concentrations of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), irisin, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) were measured prior to and after the 8-week training intervention.<bold>Results: </bold>Both exercise interventions decreased IL-6 and hs-CRP (p < 0.05), and increased adiponectin (p < 0.01) levels; changes in these variables were greater in the ET + GTE group compared to the ET + P and P groups (p < 0.01). Irisin concentrations increased only in the ET + GTE group and were different from the ET + P and P groups (p < 0.01). There were no changes in TNF-α concentrations in any of the groups. Both exercise interventions (ET + GTE and ET + P) decreased bodyweight, body mass index (BMI), body fat percentage (BFP), and visceral fat area (VFA) (p < 0.05), with greater changes in these variables occurring in the ET + GTE group compared to ET + P and P groups (p < 0.01).<bold>Conclusion: </bold>The combination of GTE supplementation and ET produces beneficial anti-inflammatory and metabolic effects, which were greater than those produced by ET alone.
- Subjects
TEA extracts; GREEN tea; OVERWEIGHT men; MIDDLE-aged men; BODY composition; INFLAMMATION treatment; OBESITY treatment; THERAPEUTIC use of plant extracts; FIBRONECTINS; C-reactive protein; RESEARCH; HERBAL medicine; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; RANDOMIZED controlled trials; PEPTIDE hormones; PLANT extracts; STATISTICAL sampling
- Publication
European Journal of Applied Physiology, 2020, Vol 120, Issue 4, p915
- ISSN
1439-6319
- Publication type
journal article
- DOI
10.1007/s00421-020-04332-6