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- Title
ASMT determines gut microbiota and increases neurobehavioral adaptability to exercise in female mice.
- Authors
Liu, Weina; Huang, Zhuochun; Zhang, Ye; Zhang, Sen; Cui, Zhiming; Liu, Wenbin; Li, Lingxia; Xia, Jie; Zou, Yong; Qi, Zhengtang
- Abstract
N-acetylserotonin O-methyltransferase (ASMT) is responsible for melatonin biosynthesis. The Asmt gene is located on the X chromosome, and its genetic polymorphism is associated with depression in humans. However, the underlying mechanism remains unclear. Here, we use CRISPR/Cas9 to delete 20 bp of exon 2 of Asmt, and construct C57BL/6J mouse strain with Asmt frameshift mutation (Asmtft/ft). We show that female Asmtft/ft mice exhibit anxiety- and depression-like behaviors, accompanied by an obvious structural remodeling of gut microbiota. These behavioral abnormalities are not observed in male. Moreover, female Asmtft/ft mice show a lower neurobehavioral adaptability to exercise, while wild-type shows a "higher resilience". Cross-sectional and longitudinal analysis indicates that the structure of gut microbiota in Asmtft/ft mice is less affected by exercise. These results suggests that Asmt maintains the plasticity of gut microbiota in female, thereby enhancing the neurobehavioral adaptability to exercise. This study shows that mutations in the X chromosome gene Asmt cause anxiety and depression-like behavior in female mice. ASMT enhances the neurobehavioral responsiveness to exercise by maintaining the plasticity of the gut microbiota.
- Subjects
GUT microbiome; X chromosome; FRAMESHIFT mutation; GENETIC polymorphisms; MICE
- Publication
Communications Biology, 2023, Vol 6, Issue 1, p1
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-023-05520-8