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- Title
Dementia is associated with open-angle glaucoma: a population-based study.
- Authors
Chung, S-D; Ho, J-D; Chen, C-H; Lin, H-C; Tsai, M-C; Sheu, J-J
- Abstract
<bold>Purpose: </bold>Previous epidemiologic studies that focused on the association between open-angle glaucoma (OAG) and dementia showed inconsistent results. In the present study, we explored the association between OAG and dementia in an ethnic Chinese (i.e., Taiwanese) population using a population-based data set.<bold>Methods: </bold>We retrieved data on study subjects for this case-control study from the Longitudinal Health Insurance Database 2000. We identified 7770 patients who had a diagnosis of dementia as cases, and 7770 subjects matched in terms of sex and age, which were randomly extracted as controls. A conditional logistic regression conditioned on age group, sex, and index year was used to assess the association of dementia with previously diagnosed OAG among the sampled patients.<bold>Results: </bold>Of 15,540 patients, 1.70% had prior OAG, including 2.02% of the dementia group and 1.38% of the controls. After adjusting for patient socioeconomic characteristics and comorbid medical disorders, dementia patients were more likely to have had prior OAG than controls (odds ratio (OR): 1.44; 95% confidence interval (CI): 1.12-1.85; P<0.01). In addition, female dementia patients were more likely to have had prior OAG than controls (OR: 1.93; 95% CI: 1.35-2.77; P<0.001), whereas no statistical difference in prior OAG between male dementia patients and controls was found.<bold>Conclusions: </bold>Female dementia patients were associated with a higher proportion of prior OAG than were the controls.
- Subjects
TAIWAN; OPEN-angle glaucoma; DEMENTIA patients; DIAGNOSIS of dementia; HEALTH insurance; MEDICAL databases; EPIDEMIOLOGY; PATIENTS; GLAUCOMA diagnosis; HYPERTENSION epidemiology; ALCOHOLISM; ASIANS; DATABASES; DEMENTIA; DIABETES; GLAUCOMA; HYPERLIPIDEMIA; LONGITUDINAL method; NATIONAL health services; DISEASE prevalence; CASE-control method; ODDS ratio
- Publication
Eye, 2015, Vol 29, Issue 10, p1340
- ISSN
0950-222X
- Publication type
journal article
- DOI
10.1038/eye.2015.120