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- Title
Antikoagülan/Antiagregan İlaç Kullanımının Mesane Kanserinin Primer Tanı Evresine Etkisi: Retrospektif Kesitsel Çalışma.
- Authors
ÇİLESİZ, Nusret Can; AVCI, Mustafa Asım
- Abstract
Objective: We aimed to investigate the effect of anticoagulant and/or anti-aggregant drug use on the stage of diagnosis of the disease in patients with primary bladder cancer after macroscopic hematuria. Material and Methods: The study was conducted retrospectively among patients with primary bladder cancer after the development of macroscopic hematuria. Age, gender, smoking, American Society of Anesthesiology scores of the patients were recorded. Patients with nonurothelial bladder cancer, carcinoma in-situ, and adjacent organ invasion were not included. The tumor number, size, T stage and tumor grade of the patients were recorded. European Association of Urology bladder cancer risk group (low, moderate, or high) were recorded. The patients were divided into two groups as AAT (+) and AAT (-) according to their use of anticoagulant and/or anti-aggregant therapy (AAT). Sociodemographic characteristics, histopathological characteristics of the both groups were analyzed comparatively. Results: A total of 153 patients who were retrospectively screened and met the criteria were included in the study. The mean age of the patients was 64.69±12.25. It was calculated that 54 (35.2%) of the patients were in the AAT (+) and 99 (64.8%) patients were in the AAT (-) group. There was no significant difference in terms of age, gender and tumor number (p>0.05). Although the proportion of patients with tumor size <3 cm (75.9% vs. 62.6%; p=0.091) was higher in the AAT (+) group, no significant difference was observed. The rate of muscle invasive disease (>T2) (17.1% vs 3.7%; p=0.015) and high-grade bladder cancer rate (46.4% vs. 27.7%; p=0.024) were calculated to be higher in the AAT (-) group. According to the recurrence risk score, patients with a European Cancer Research and Treatment Organization score of =5 (66.6% vs. 45.4%; p=0.012) were found to be more common in the AAT (+) group. Conclusion: It was concluded that the use of AAT provoked the development of macroscopic hematuria and enabled the detection of bladder cancer at an earlier stage.
- Publication
Journal of Reconstructive Urology, 2023, Vol 13, Issue 2, p47
- ISSN
2587-0483
- Publication type
Article
- DOI
10.5336/urology.2023-95961