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- Title
Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the stage for a network-based approach to rehabilitation.
- Authors
Sandroff, Brian M.; Wylie, Glenn R.; Sutton, Brad P.; Johnson, Curtis L.; DeLuca, John; Motl, Robert W.
- Abstract
Exercise training has been identified as a highly promising approach for managing the cognitive consequences of multiple sclerosis (MS). This study represents a secondary analysis of resting-state functional connectivity (RSFC) magnetic resonance imaging data from a pilot treadmill walking exercise training intervention for improving cognitive processing speed (CPS) in MS. There were large intervention effects on RSFC between the thalamus and right superior frontal gyrus (d = 1.92) and left medial frontal gyrus (d = 1.70). There further were moderate-to-large intervention effects on CPS (d = 0.72). Such preliminary data highlight FC within thalamocortical circuitry as a potential target for rehabilitation interventions for improving CPS in cognitively impaired individuals with MS.
- Subjects
MULTIPLE sclerosis; TREADMILL exercise; BRAIN physiology; MEDICAL rehabilitation; MAGNETIC resonance imaging of the brain
- Publication
Multiple Sclerosis Journal - Experimental, Translational & Clinical, 2018, Vol 4, Issue 1, p1
- ISSN
2055-2173
- Publication type
Article
- DOI
10.1177/2055217318760641